Source  JOURNAL OF INTEGRATIVE PLANT BIOLOGY

Published JUL 2025

DOI: 10.1111/jipb.13901

IF9.5

Abstract 

Crop varieties with broad-spectrum resistance (BSR) are highly beneficial, as they provide resistance against the majority of races within the same species of pathogen or even across multiple pathogen species (Li et al., 2020). Plant breeders usually introduce dominant resistance (R) genes in their breeding programs. However, these genes often recognize cognate avirulence effectors, resulting in race-specific resistance against a single or few pathogen strains (Li et al., 2019, 2020). Recent studies have suggested that disabling some susceptibility (S) genes in elite cultivars could significantly enhance quantitative resistance, but the level of resistance is much less than qualitative resistance (van Schie and Takken, 2014; Tao et al., 2021; Gao et al., 2024). Therefore, combining R gene stacks with S genes editing may represent an excellent strategy for achieving BSR and durable resistance (Deng et al., 2020; Jones et al., 2024).